ACORN Study
Advancing genetic research to prevent MND
The Alan Davidson Foundation has played a central role in supporting the “Making MND Preventable – ACORN” project, a landmark research initiative led by the University of Oxford and the Nuffield Department of Clinical Neurosciences. This multi-year commitment reflects the Foundation’s dedication to advancing innovative research into Motor Neuron Disease (MND), particularly in the areas of early detection, prevention, and targeted treatment.
The ACORN Study: A national effort
Launched in December 2023, the ACORN study is a comprehensive research initiative that aims to recruit between 300 and 1,450 participants across the UK. The study focuses on individuals with MND or FTD who have the C9orf72 gene expansion, as well as their asymptomatic family members and healthy volunteers. By collecting and analysing biological samples, such as blood, skin, and cerebrospinal fluid, along with conducting advanced imaging and neurophysiological tests, researchers aim to identify early biomarkers and understand the disease’s progression.
A significant aspect of the ACORN project is the creation of a national register of individuals carrying the C9orf72 mutation. This registry will facilitate future research and clinical trials, enabling scientists to monitor at-risk individuals over time and potentially intervene before the onset of symptoms.
Alan Davidson Foundation’s role
The Alan Davidson Foundation’s continued investment in the ACORN project underscores its dedication to improving the lives of individuals affected by MND. In addition to funding the project’s core research activities, the Foundation has committed to covering one-third of the cost for a new Clinical Research Fellow position, set to commence in Autumn 2025. This role will be instrumental in advancing the study’s objectives, including participant recruitment, data analysis, and dissemination of findings.
Looking ahead
The ACORN project represents a significant step forward in the fight against MND. By focusing on the genetic factors that contribute to the disease, researchers aim to develop strategies that could prevent or delay its onset. The Alan Davidson Foundation’s continued support ensures that this vital research can progress, offering hope for a future where MND is a preventable condition.
